An American Academy of Neurology (AAN) Guideline
Subcommittee updated a 1996 practice parameter for discontinuing antiseizure
medications (ASMs) in seizure-free patients. New practice recommendations for
children and for adults have come forth. (1)
The reviewers addressed questions about patients who
have been seizure-free at least 12 months and who are still on ASMs. Does
stopping ASMs: (1) increase the risk of seizure recurrence, and are there
factors that increase the risk for recurrence? (2) increase
the risk of status epilepticus (continuous seizures without ceasing)? (3) reduce
medication-related side effects? (4) change the risk of death? (5) change any
of the above risks based on the speed of withdrawal? and (6) change quality of
life?
The important quality of life questions starts with if
you cut back medications, we can’t really predict if restarting the same
medication will work again—there’s a small chance it won’t. Then other
medications may or may not work as well and they may have their own side-effects.
Discuss your driving issues: should you cease driving for a while as you
discontinue ASMs? How long? Will your state’s DMV make the decision and/or your
doctor? Consider seizure occurrence on the job, participation in recreation
activities, etc. A discussion regarding recurrence in epilepsy patients who
have had successful epilepsy surgery and who are now seizure-free still on ASM
medications would be problematic.
The main conclusion is that after two years
seizure-free, medication withdrawal can be considered in adults whereas in kids
its’ more likely that it could be considered after 18-24 months seizure-free.
In considering ASM withdrawal in adults there is no real way to predict
outcomes. In kids we can use the EEG, as there are pediatric electroclinical
syndromes that could be detected on an EEG and if present makes it unlikely
that ASM withdrawal will be successful. Note that half of all epilepsy patients
will have a normal EEG at any one time since abnormal epileptiform activity is
not continuous. Judgement is the critical component for making decisions.
The AAN subcommittee concluded the risk for seizure
recurrence among adults who were seizure-free for two years and who tapered off
vs those who did not taper but who stopped suddenly was not statistically
different (15% vs 7%). In pediatric cases the difference in seizure recurrence between
those who taper off after 18 months of being seizure free vs after 24 months was
probably not significant. Only in kids are recommendations for the rate of
ASM-withdrawal specific, not in adults: it’s recommended withdrawal in children
at a rate no faster than 25% every 10-14 days.
The recommendations serve as talking points between
clinicians and their patients and their families. The relationship between ASM
withdrawal and the risk of mortality and status epilepticus is not as strong.
But if your seizures are frequent and you stop your ASMs there’s a greater risk
of your having status epilepticus.
1)
AAN
Guideline Subcommittee. Antiseizure Medication Withdrawal in Seizure-Free
Patients: Practice Advisory Update Summary. Neurology Dec 7, 2021; Vol 97
(23) 1072-1081.
Lance Fogan, M.D. is
Clinical Professor of Neurology at
the David Geffen School of Medicine at UCLA. His hard-hitting emotional family medical drama, “DINGS, is told from a
mother’s point of view. “DINGS” is his first novel. Aside from
acclamation on internet bookstore sites, U.S. Report of Books, and the
Hollywood Book Review, DINGS has been advertised in a recent Publishers Weekly,
New York Times Book Review, and the Los Angeles Times Calendar section. DINGS
teaches epilepsy and is now available in eBook, audiobook, and soft and hard
cover editions.
