Sunday, August 26, 2018

Blog #97: A REMINDER: SLEEP LOSS AND EPILEPSY

Epileptic seizures and sleep cycles is a complex realm of neuroscience that will not be addressed here. 

Epileptic seizures are often precipitated by a combination of various clinical factors, but, we find that sleep loss stands out as an independent seizure-trigger in neurology clinics. This variable can be controlled by our epilepsy patients. 

Below is a representative study. It supports obtaining adequate sleep of eight hours per night. In a prospective, observational cross-over study, 179 consecutive hospital admissions for epileptic seizures were included.1 The sleep duration prior to the seizure, as well as alcohol, caffeine and drug use, were recorded.

Complete data for analysis were retrieved in 144 patients. The sleep-time during the 24 hours prior to the seizure was lower (7.3 hours) compared to follow-up (8.3 hours) longer seizure-free periods. Caffeine consumption and use of relevant non-antiepileptic drugs (AED) were not different.

I emphasize that sleep-rest is critical in helping control epilepsy. Be sure to get an adequate night’s sleep, preferably at least eight hours to support your anti-convulsant medications.



1)      Samsonsen C, Sand T, BrĂ¥then G, et.al. The impact of sleep loss on the facilitation of seizures: A prospective case-crossover study. Epilepsy Research November 2016, Volume 127, Pages 260-266.




Lance Fogan, M.D. is Clinical Professor of Neurology at the David Geffen School of Medicine at UCLA. “DINGS” is his first novel. It is a mother’s dramatic story that teaches epilepsy, now available in eBook, audiobook and soft cover editions.






Thursday, July 26, 2018

Blog #96: Neurologists May Be Missing the Higher Risk of Suicide/Drug Overdose in Epilepsy Patients

            A troubling picture is emerging: the deadly side of epilepsy. Epilepsy patients have a higher risk of unnatural death compared with the non-epilepsy population. SUDEP (Sudden Unexplained Death in Epilepsy) is not common, but suicide and drug overdose and other unnatural causes are.

            In the general population the actual risk of unnatural death is 0.3 to 0.5 percent of total deaths. People with epilepsy are five times more likely to die because of accidental poisoning from medication and three times more likely to die from an intentional overdose of medication compared to people who don’t have epilepsy. Although the researchers were already aware that people with epilepsy are at a higher risk of death, “…we didn’t know much about the risks of different types of death.”1

            This population-based cohort study included more than 50 000 people with epilepsy and 1 million matched individuals without epilepsy who had identified in two data sets drawn from the general populations of England and Wales. Researchers reported people with epilepsy had a 3-fold increased risk of any unnatural mortality and a 5-fold increased risk of unintentional medication poisoning. Psychotropic and opioid drugs were most commonly used in poisoning, but not antiepileptic drugs. 

            Since people with epilepsy are at increased risk of unnatural death, they and their families should be advised about unintentional injury prevention and monitored for suicidal ideation, thoughts, and behaviors. The suitability and toxicity of concomitant medication should be considered when prescribing for comorbid conditions.
            Elizabeth Donner, MD,2 director of the Comprehensive Epilepsy Program at the Hospital for Sick Children in Toronto, said, “Having good seizure control doesn’t mean the person with epilepsy is otherwise trouble-free or experiencing a good quality of life.” She added that death certificates may not list epilepsy as a contributing cause in suicide or drug overdose cases.
                Psychological counseling should be recommended for our patients who are at risk. A low threshold must be entertained for preventive education and intervention. Clinicians should query patients and their families about depression and addictive/and or dangerous behaviors to attempt to avoid tragedy.              
                
1.      Gorton CH, PhD; Webb RT, PhD; Carr MJ. PhD; et al. Risk of Unnatural Mortality in People With Epilepsy. JAMA Neurol. Published online April 9, 2018.
2.      Neurology Today. Volume 18/issue 10: May 17, 2018
 

Lance Fogan, M.D. is Clinical Professor of Neurology at the David Geffen School of Medicine at UCLA. “DINGS” is his first novel. It is a mother’s dramatic story that teaches epilepsy, now available in eBook, audiobook and soft cover editions.

Monday, June 25, 2018

Blog #95: A FAMILY DEALS WITH UNRECOGNIZED EPILEPSY: Excerpted from Dr. Lance Fogan’s medical mystery novel, DINGS.

Follow a family as they are immersed in a medical mystery: why is their 8 yr old failing school? Read an excerpt from DINGS at LanceFogan.com.  










 
Chapter 22, Part 1

The following week I returned from an early-afternoon errand with Madison and received the call I had been waiting for. I phoned Sam in a flush of excitement. “Honey? Sam? The neurologist’s office just called. Conner’s appointment is on Friday after school. Isn’t that great? I think—I hope—Conner will be able to stop taking those pills then.”
“That would be great, but we don’t know if the doctor will stop them—not for sure. We shouldn’t get our hopes up prematurely, Sandra.”
Why did he always have to do that? Why did he always have to smother my confidence, my optimism? Why couldn’t he just agree and be hopeful, too? “I know, Sam, but Dr. Choy told us that all of Conner’s tests were normal. Even he said that the neurologist probably would stop the Dilantin. Remember? He said that. I remember it. Don’t you?”
I was holding on, clinging to my very own one-person “lifeboat.” I knew that this was illogical, wishful magical thinking, but I would not let go of these hopes.
“No, Sandra. He said—whatever. Fine. We will clear everything up on Friday. That will be good for Conner. It’ll be good for all of us.”
This was not what I wanted or needed to hear: his typical pessimism. He would say it was his realism. “We’re having steak for dinner. ’Bye.” I hung up.
***
“What are you doing, Mommy?” Madison had padded down the stairs to find me circling the kitchen like a merry-go-round. I had been singing and clanging pans together preparing to bake.
“I’m going to make a special dessert for tonight, honey—a surprise for Daddy and Conner. Chocolate biscotti! Do you want to help Mommy, little one?”
I hummed and twirled as I opened cupboards and brought out more ingredients. I grabbed a bag of gourmet-chocolate nuggets and a bag of walnuts. “We all love my chocolate biscotti, and there’s just enough time to make it before our men get home. Do you know what, precious one? Conner should be able to stop taking those pills in two days. Two days! Won’t that be great, sweetheart?”
I whirled like a dervish. I glided and spun from the refrigerator to the cupboard to the cutting board and back again as I poured and measured, mixed, kneaded and chopped the ingredients.
I tied an apron around Madison’s little waist. She knelt on a chair at the kitchen table and pushed a rolling pin back and forth over an empty cutting board. She hummed with me, too.
I put the tray of biscotti into the oven. The essence of chocolate filled the kitchen. I telephoned my parents to tell them about Conner’s upcoming appointment and reconfirmed that no one else in our family ever had seizures. Then I called Kathy and Marge, my two closest friends, to share my excitement.
“…Yes, Conner should be able to stop taking those pills in two days. I really hope so, I pray so. It’s what I’ve read on the Internet. We’ll finally get to the bottom of this whole nightmare, and that should be the end of it.”
When Sam and Conner came home, I hugged and kissed them and hurried them off to wash for supper. Everyone loved the meal.
After we put the children to bed, Sam and I lingered over wine, talking on the couch in the den. It had been a good day—until now. I drank more than usual, a second glass just so he couldn’t drink the whole bottle by himself. He wanted to start a second bottle. “No, Sam. We’ve both had enough. You, especially. Please! You need to cut back. You never used to drink this much.”
His lips curled with a defiant glare. I froze. No arguments now, please…
He got up and brought out another bottle from the cabinet. Then his eyes darted swiftly between the bottle and me while he seemed to consider the situation. Slowly, he articulated each syllable: “I’m not ready to cut back, as you say.”
“Oh Sam. There’s so much happening with our family. I’m starting to think that we might not survive this.”
“Aw, c’mon. What are you talking about? It’s not that serious.” He began to cut off the cover over the cork.
I sat forward and looked up at him. “I’m telling you how it is, Sam. Now I’m going to tell you something else—something about me. I admit it. I’ve buried what’s really happening. I know that’s what you think. Nevertheless, I just had to. I’m so worried about Conner and for all of us. No one has yet told us why he had that convulsion. Not really. I’ve swallowed what Choy and Bob Jackson fed me—that the neurologist will agree with what they both told us. That he could stop the Dilantin. What if this neurologist finds something terrible in Conner’s brain even if the tests were normal? I’ve read about all kinds of terrible diseases on the Internet. Doctors make mistakes; it happens all the time. Everybody knows that. I need you with me now. Now, especially…” I felt drops roll down my cheeks and wetness ooze from my nose as I stared up into his face. I pulled out a tissue from my pocket.
His expression softened. “I—I—Okay, honey. Conner will be all right. You’ll see. He’s a strong kid.” He lowered himself onto the couch next to me with the dark bottle still in his hand. He laid the corkscrew on the coffee table. “I’m sorry. I hear you. Yeah. Okay. No more, tonight. I have been trying to cut back, honey. I have. It’s hard.” He stood the bottle on the coffee table and put his arm around my shoulders. I curled into his chest as he pulled me toward him.
“Oh, Sam.” My tenseness eased.
“Come on, honey. You’re so wound up with all these suppositions: they’ll stop the medicines; he’ll be on them forever. Just ease up and go with the flow. Isn’t that what you’ve always said? It’ll work out. Come on, Sandra. Remember Mark Twain? He was right. He’d ‘crossed many a bridge that never was there.’”
I looked into his eyes and managed a weak smile. “So, now you’re the one glossing over the problem and encouraging me? Nice.”



Lance Fogan, M.D. is Clinical Professor of Neurology at the David Geffen School of Medicine at UCLA. “DINGS” is his first novel. It is a mother’s dramatic story that teaches epilepsy, now available in eBook, audiobook and soft cover editions.